- 1891 – James A. MacAlister
- 1913 – Hollis Godfrey
- 1922 – Kenneth Matheson
- 1932 – Parke R. Kolbe
- 1942 – George Peters Rea
- 1945 – James Creese
- 1963 – William W. Hagerty
- 1984 – William S. Gaither
- 1987 – Harold Myers (interim)
- 1988 – Richard Breslin
- 1994 – Chuck Pennoni (interim)
- 1995 – Constantine N. Papadakis
- 2009 – Chuck Pennoni (interim)
- 2010 – John A. Fry
Drexel’s 14th president, John Anderson Fry, arrived at Drexel University in 2010 from Franklin & Marshall College, bringing with him a wealth of higher education expertise through a career as a consultant, board member, chief operating officer, CEO and executive vice president at the University of Pennsylvania.